Single nucleotide polymorphism rs7908486 of the TCF7L2 gene is highly associated with obesity in the Iraqi population
نویسندگان
چکیده
This study was conducted to assess the possible association between polymorphisms of transcription factor 7-like 2 (TCF7L2) gene and obese Iraqi adults. DNA obtained from 158 subjects 142 controls. Two specific PCR fragments were designed incorporate two highly frequent single nucleotide polymorphism (SNP)s within TCF7L2, rs11196208 rs7908486. Both amplified loci genotyped by PCR-single-strand conformation (SSCP) followed sequencing. Logistic regression analysis performed detect both genetic variants obesity. Concerning rs11196208-based amplicons, PCR-SSCP genotyping showed homogeneous banding patterns for all investigated samples. In contrast with rs11196208, three SSCP in rs7908486-based GG, AG AA, observed. Individuals AA genotype significantly higher (P<0.05) body mass index (BMI), waist circumference (WC), fasting blood glucose (FBG), insulin values than those either or GG genotypes. Association revealed that individuals A allele exhibited a greater risk obesity B allele. Data indicate rs7908486 SNP exerted tight The suggests implementing TCF7L2 early detection
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ژورنال
عنوان ژورنال: Archives of Biological Sciences
سال: 2021
ISSN: ['1821-4339', '0354-4664']
DOI: https://doi.org/10.2298/abs201213056m